Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury

نویسندگان

  • Arash Moghaddam
  • Christopher Child
  • Thomas Bruckner
  • Hans Jürgen Gerner
  • Volker Daniel
  • Bahram Biglari
چکیده

Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Vascular Endothelial Growth Factor) over a 12-week period in 40 acute traumatic SCI patients: at admission on average one hour after initial trauma; at four, nine, 12, and 24 h; Three, and seven days after admission; and two, four, eight, and twelve weeks after admission. This was done using a Luminex Performance Human High Sensitivity Cytokine Panel. SCI was classified using the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at time of admission and after 12 weeks. TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission and in patients with an initial AIS A (p < 0.05). This study shows significant differences in cytokine concentrations shown in traumatic SCI patients with different neurological impairments and within a 12-week period. IL-8 and IL-10 are potential peripheral markers for neurological remission and rehabilitation after traumatic SCI. Furthermore our cytokine expression pattern of the acute, subacute, and intermediate phase of SCI establishes a possible basis for future studies to develop standardized monitoring, prognostic, and tracking techniques.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cellular and Molecular Mechanisms Involved in Neuroinflammation after Acute Traumatic Spinal Cord Injury

Introduction: Spinal cord injury (SCI) following traumatic events is associated with the limited therapeutic options and sever complications, which can be partly due to inflammatory response. Therefore, this study aims to explore the role of inflammation in spinal cord injury. The findings showed that the pathological conditions of nervous system lead to activation of microglia, astrocyte, neut...

متن کامل

Neuroprotective effects of atomoxetine against traumatic spinal cord injury in rats

Objective(s):Spinal cord injury (SCI) often causes serious and irreversible neurological deficit leading to disability or impairment of normal physical activity. Atomoxetine, a selective norepinephrine transporter (NET) inhibitor has gained much attention in the field of the neurodevelopmental disorder, but its effect on SCI has not been evaluated. The present study has been undertaken to inves...

متن کامل

Factors Affecting Post Traumatic growth in Patients with Spinal Cord Injury: A Phenomenological Study

Introduction: Spinal cord injury is one of the problems of human societies, which causes many physical and emotional problems for a person and will have consequences for personal, family and social problems. The purpose of this study was to investigate the phenomenological factors affecting post-traumatic growth in patients with spinal cord injury. Methods: The qualitative research project was ...

متن کامل

P 94: The Systemic Inflammation after Spinal Cord Injury

Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord ...

متن کامل

Review of studies on Mechanical Performance of Spinal Cord in Traumatic Injuries

Considering the extent of the disability caused by spinal cord injury and the increasing incidence of it, many attempts have been made to understand how this lesion is repaired. Most of the spinal cord injuries are traumatic injuries. The annual incidence of this damage is estimated between 15-40 cases per million people worldwide. Considering the extent of this incident, the need for study of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 16  شماره 

صفحات  -

تاریخ انتشار 2015